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Studies on pyrrolidinones. Preparation of 1,5,6-10b-tetrahydro-2H-pyrrolo[1,2-c]quinazoline-3-ones from pyroglutamic acid

✍ Scribed by Samira El Ghammarti; Benoít Rigo; Hechmi Mejdi; Jean-Pierre Hénichart; Daniel Couturier

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
475 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Tetrahydro‐2__H__‐pyrrolo[1,2‐c]quinazoline‐3‐ones are easily obtained from the Friedel‐Crafts cyclization of N‐arylaminomethyl pyroglutamic acids. This reaction occurrs via an acyliminium salt formed by decarboxylation of the acid function.

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