Studies on polypeptides. XXXV. Synthesis of a partially protected heptapeptide, corresponding to the sequence 14–20 of bovine pancreatic ribonuclease

✍ Scribed by P. Hoogerhout; Cecile Schattenkerk; K. E. T. Kerling

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 249 KB
• Volume: 100
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19811000905

✦ Synopsis

Abstract

The partially protected heptapeptide, Boc—Asp(OtBu)—Ser—Ser‐Thr‐Ser‐Ala‐Ala‐OH, corresponding to the sequence 14‐20 of bovine pancreatic ribonuclease, was prepared by a combination of solid‐phase synthesis using N^α^‐(9‐fluorenylmethoxycarbonyl) amino acids and synthesis in solution by the active ester method. The overall yield was 38%.