Studies on polypeptides XXX. Replacement of histidine-12 by β-(4-pyridyl)-L-alanine in RNase S': (Preliminary communication)

Studies on polypeptides XXXII: Solid-pha

Studies on polypeptides XXXII: Solid-phase synthesis of RNase S-peptide 1-14 analogues; replacement of histidine-12 by β-(2-pyridyl)-L-alanine and β-(4-pyridyl)-L-alanine

✍ C. Hoes; J. Raap; W. Bloemhoff; K. E. T. Kerling 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 627 KB

## Abstract The synthesis of two analogues of the __N__‐terminal tetradecapeptide of ribonuclease A (RNase S‐peptide 1‐14), in which the active site histidine‐12 residue is replaced by β‐(2‐pyridyl)‐__L__‐alanine and β‐(4‐pyridyl)‐__L__‐alanine, has been accomplished by the solid‐phase method. The