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Studies on polypeptides. Part X: Synthesis of 1-13[10-Homoarginine, 13-Leucine] bovine pancreatic ribonuclease by combined solid-phase and classical methods

✍ Scribed by S. Visser; K. E. T. Kerling; E. Havinga

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 218 KB
Volume: 89
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19700890814

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✦ Synopsis

Abstract

Merrifield's solid‐phase method was applied to the synthesis of all‐L‐glutamyl‐homoarginylglutaminylhistidylleucine. Azide coupling in solution with all‐L‐N^α^, N^ϵ^‐di‐t‐butoxycarbonyllysyl‐γ‐t‐butylglutamylthreonylalanylalanylalanyl‐N^ϵ^‐benzyloxycarbonyllysylphenylalanine hydrazide, also prepared on a solid supportS. Visser, J. Roeloffs, K. E. T. Kerling and E. Havinga, ibid. 87, 559 (1968).

, resulted in the N‐terminal tridecapeptide sequence of bovine pancreatic ribonuclease in which homoarginine and leucine replace arginine‐10 and methionine‐13, respectively.

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