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Studies on Polypeptides. IX. Synthesis of Peptides Containing Basic Amino Acid Residues, Related to Corticotropin and Intermedin

✍ Scribed by Hofmann, Klaus; Kappeler, Heini; Furlenmeier, Andreas E.; Wooner, Miriam E.; Schwartz, Eleanore T.; Thompson, Thomas A.


Book ID
126040937
Publisher
American Chemical Society
Year
1957
Tongue
English
Weight
595 KB
Volume
79
Category
Article
ISSN
0002-7863

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Studies on Amino Acids and Peptides, 11.
✍ Andersen, Torben P. ;Senning, Alexander 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 608 KB

The newly synthesized amino acid (S)-5-thioxoproline ((sj-Top OH) (1) has been coupled with HCI \* H-(S)-Leu-GlyNRR 6 by the mixed anhydride method. The resulting tripeptide amides (Sy-Top-(Sf-Leu-GlyNRR' 7 are new analogues of the hypothalamic factor MIF. The intermediatcs 6 were synthesiirzd by am