Studies on Amino Acids and Peptides, 11.
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Andersen, Torben P. ;Senning, Alexander
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Article
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1987
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John Wiley and Sons
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English
⚖ 608 KB
The newly synthesized amino acid (S)-5-thioxoproline ((sj-Top OH) (1) has been coupled with HCI \* H-(S)-Leu-GlyNRR 6 by the mixed anhydride method. The resulting tripeptide amides (Sy-Top-(Sf-Leu-GlyNRR' 7 are new analogues of the hypothalamic factor MIF. The intermediatcs 6 were synthesiirzd by am