✦ LIBER ✦

Studies on penam sulfones III. Synthesis and β-lactamase inhibitory activity of sodium (6R)-6-(α-hydroxybenzyl)-2β-methoxyiminomethyl-2α-methylpenam-3α-carboxylate 1,1-dioxide and sodium 2β-acyl-2α-methylpenam-3α-carboxylate 1,1-dioxide

✍ Scribed by David P Czajkowski; Andhe V.N Reddy; Eduardo L Setti; Oludotun A Phillips; Ronald G Micetich; Chieko Kunugita; Samarendra N Maiti

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 199 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00575-6

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✦ Synopsis

The synthesis and in vitro synergies of (6R)-6-(~-hydroxybenzyl)-2[~-methoxyiminomethyl-2~methylpenam-30~-carboxylate 1,1-dioxide (4) and 2~-acyl-2~-methylpenam-3ct-carboxylate l,l-dioxide (15) are described. Compound 15 showed good in vitro synergy in combination with piperacillin and ceftazidime against chromosomally mediated class I cephalosporinase producing organisms including TEM, SHV, and OXA-type enzymes producing microorganisms.

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