Studies on osmotic fragility of red blood cells determined with a coil planet centrifuge for workers occupationally exposed to lead
✍ Scribed by Ichiro Karai; Koichi Fukumoto; Shun'ichi Horiguchi
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 392 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0340-0131
No coin nor oath required. For personal study only.
✦ Synopsis
In order to clarify the relationship between lead exposure level and osmotic fragility of red blood cells determined by the coil planet centrifuge method, several clinical laboratory examinations were performed on 27 male workers employed in a scrap lead refining factory using as controls 40 male workers employed in railway construction The examinations included measurement of red blood cell and reticulocyte counts, hematocrit, MCV, blood and urine lead concentrations, urine coproporphyrin, and urine b-aminolevulinic acid The results were:
1 Osmotic fragility of red blood cells was lower in lead workers at all three hemolytic points compared with the controls Significant difference was observed in hemolysis of the maximum point (P < 0 05).
2 The red blood cell and reticulocyte counts, hematocrit value and MCV of the lead workers were not significantly different from those of the controls.
Values for blood and urine lead, coproporphyrin, and 6-aminolevulinic acid of the lead workers were much higher than those of the controls (P < 0 01).
3 In lead workers, close relationships between the osmotic fragility and these laboratory findings were observed: blood lead, r=-0 572, P< 0 01 ; coproporphyrin, r=-0 608, P< 0 01 ; -aminolevulinic acid, r=-0 559, P< 0.01 ; urine lead, r=-0 453, P< 0 05.