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Studies on novel and chiral 1,4-dihydropyridines. V. Hantzsch-type 1,4-dihydropyridines having a chiral sulfinyl group: Syntheses, structures, and biological activity as a calcium channel antagonist

✍ Scribed by Kazuyuki Miyashita; Masahiro Nishimoto; Tetsuya Ishino; Hidenobu Murafuji; Satoshi Obika; Osamu Muraoka; Takeshi Imanishi

Book ID
104207691
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
734 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

4-Aryl and 4-methyl substituted Hantzsch-type 1,4-dihydropyridines having a chirat sulfinyl group as an electron-withdrawing group were successfully synthesized in an optically active form from [~-ketosulfoxides via two routes. The relationship between calcium channel antagonist activity and the structures of 4-aryl derivatives was also studied.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Studies on Novel an
ChemInform Abstract: Studies on Novel and Chiral 1,4-Dihydropyridines. Part 5. Hantzsch- Type 1,4-Dihydropyridines Having a Chiral Sulfinyl Group: Syntheses, Structures, and Biological Activity as a Calcium Channel Antagonist.
✍ K. MIYASHITA; M. NISHIMOTO; T. ISHINO; H. MURAFUJI; S. OBIKA; O. MURAOKA; T. IMA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

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