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Studies on novel and chiral 1,4-dihydropyridines. III. Asymmetric reduction of some ketones with novel NADH model compounds, (SS)-3-(p-Tolylsulfinyl)-1,4-dihydropyridines

โœ Scribed by Satoshi Obika; Toshihiko Nishiyama; Satoshi Tatematsu; Kazuyuki Miyashita; Chuzo Iwata; Takeshi Imanishi

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
565 KB
Volume
53
Category
Article
ISSN
0040-4020

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๐Ÿ“œ SIMILAR VOLUMES

Studies on novel and chiral 1,4-dihydrop
Studies on novel and chiral 1,4-dihydropyridines. IV. Mechanistic aspects of the asymmetric reduction with chiral NADH model compounds, (SS)-3-(p-tolylsulfinyl)-1,4-dihydropyridines
โœ Satoshi Obika; Toshihiko Nishiyama; Satoshi Tatematsu; Kazuyuki Miyashita; Takes ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 537 KB

In the reduction of ketones with NADH mimics, (Ss)-l-substituled 3-(p-tolylsulfinyl)-1,4-dihydropyridines 1, the stereospecific transfer of one of the C-4 hydrogens, which is syn to the S-O bond, was experimentally revealed to be involved by employing the 2-methyl derivative 2 and the 4-deuterated d