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STUDIES ON MORPHINE DISPOSITION: INFLUENCE OF RENAL FAILURE ON THE KINETICS OF MORPHINE AND ITS METABOLITES

โœ Scribed by SEAR, J. W.; HAND, C. W.; MOORE, R. A.; McQUAY, H. J.


Book ID
126646983
Publisher
Oxford University Press
Year
1989
Tongue
English
Weight
385 KB
Volume
62
Category
Article
ISSN
0007-0912

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The disposition of morphine (MOR) and its metabolites in the rabbit was measured after topical administration of its hydrochloride salt (MOR. HCI), and their time course was compared with those after intravenous and oral administration. The area under the plasma concentration-time curve (AUC) ratio