Studies on interactions involving antidepressive and other drugs with tetrabenazine and noradnamine on locomotor activity in mice, including details of the experimental design and statistical analysis
✍ Scribed by B. J. Jones; B. D. Tolman; D. J. Roberts
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 662 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
A method for the measurement of drug interactions on locomotor activity in mice has been described. The experiments were designed on a factorial basis and the data obtained were subjected to variance analysis.
Using the principles described, the effects of various drugs on the hypoactivity induced by noradnamine or tetrabenazino were studied. Twenty potential drug interactions were examined, but only seven of those exhibited statistically significant interaction. Tetrabonazine hypoactivity was antagonised by nortriptyline, amitriptyline, nialamido and nora4namine. The latter also potentiated the effect of a low dose of tetrabonazine. Hypoaetivity induced by noradnamine was antagonised by amitriptyline and nortriptylino, potentiated by atropine but unaffected by nialamide. The significance of those findings is discussed.