Studies on IgE production in mice

✍ Scribed by Yoshihiro Kumagai; Takao Hirano; Naohiro Watanabe; Ko Okumura; Zoltan Ovar

• Book ID: 104743681
• Publisher: Springer-Verlag
• Year: 1983
• Tongue: English
• Weight: 358 KB
• Volume: 18
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00368543

✦ Synopsis

IgE levels after Nipposrrongylus brasiliensis infestation were high in all strains of mice examined except in the SJA/9 strain. However, surface IgE levels on B cells were not different from those observed in the SJL strain. Most surface IgE-bearing cells also had surface IgM molecules. We suggest that the surface IgE-bearing cells are precursors of IgE-producing cells. In adoptive transfer, hapten-specific IgE antibody was produced when hapten-primed cells from SJA/9 mice were transferred together with cells from SJL donors infested with N. brasiliensis but not when the cells were from SJA/9 donors. It is suggested that the lack of collaboration between hapten-primed B cells and cells from infested mice is a genetic trait of the SJA/9 strain.