## Abstract Carbon‐14 labeled (__R__)‐3‐fluoro‐4‐(2′‐(5′′, 6′′, 7′′, 8′′‐tetrahydro‐5′′, 5′′, 8′′, 8′′‐tetramethyl‐2′′‐naphthyl)‐[2′‐hydroxy‐^14^C])[carbonyl‐^14^C]acetamidobenzoic acid, **1**, was prepared in a six step radioactive synthesis from diethyl [carboxylate‐^14^C~1,2~] oxalate. The penul
✦ LIBER ✦
Studies on hindered phenols. III. Synthesis of (±)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-yl-methoxy) benzyl]-5-14C-thiazolidine-2, 4-dione (14C-labelled CS-045)
✍ Scribed by T. Yoshioka; Y. Aizawa; T. Kanai; T. Fujita; K. Kawai
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 307 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A synthetic procedure for producing (±)‐5‐[4‐(6‐hydroxy‐2, 5, 7, 8‐tetramethylchroman‐2‐ylmethoxy) benzyl]‐5‐^14^C‐thiazolidine‐2, 4‐dione (^14^C‐labelled CS‐045) is described. The radiolabel is introduced using [5‐^14^C] thiazolidine‐2, 4‐dione, as shown in the scheme.
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## Abstract A group of radioactive 1,4‐benzodiazepine derivatives have been synthesized from glycine‐1‐^14^C. The subject compounds are labeled with carbon‐14 in the 2‐position of the 1,4‐benzodiazepine ring system.