Studies on herbal remedies I: Analysis of herbal smoking preparations alleged to contain lettuce (Lactuca sativa L.) and other natural products
✍ Scribed by Zei-Jing Huang; A. Douglas Kinghorn; Norman R. Farnsworth
- Book ID
- 102405600
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 270 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
Ascites fluid (0.1 ml) from a tumor-bearing mouse and containing lo5 cells7 was injected intraperitoneally on day zero. Each experimental group contained six male mice (20-25 g) (4). The drug was injected intraperitoneally on days 1,5, and 9 at a 120-mg/kg dose. The TIC was 85.4% for the L-1210 leukemia and 83.5% for the H-5 ascites tumor. A 360-mg/kg dose at day I or 40 mg/kg on days 1-9 in the L-1210 tumor also gave a T/C of 85.4%. A T/C value 685% indicates that the compound is probably producing a toxic response (4). This compound did not cause any deaths in control A/J or B6D2F1 mice at the doses used, nor did it cause any visible toxicity, such as weight loss.
The probable toxic response of this compound in tumor-bearing mice hindered the testing of other substituted pyrrolo(2,3-d)pyrimidine-2,4-diones for antitumor activity.