Studies on group-specific antigens in tumours induced with avian tumour viruses in rats

✍ Scribed by V. Thurzo; M. Šimkovičová; D. Šimkovič

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: French
• Weight: 454 KB
• Volume: 4
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910040614

✦ Synopsis

Group-specific complement-fixing antigen (GS antigen) was studied by the complement-fixation test in various avian and mammalian tumours, induced with the following strains of avian tumour virus ( A T V ) : Schmidt-Ruppin strain of Rous sarcoma virus ( S R -R S V ) , Prague strain of R S V ( P R -R S V ) , Fujinami sarcoma virus ( F S V ) and Bratislava 77 virus (B77V).

All primary tumours induced in chicks by S R -R S V , FSV and B77V, as well as all duck tumours induced with B77V, contained high titres of GS antigen when studied with high-titre rabbit antiserum against purified GS antigen of avian myeloblastosis virus ( A M V ) . In three out of six B77V-induced rat tumours (two virus-producing and one non-virogenic) high titres of GS antigen were detected when examined with rabbit antiserum and with some rat sera obtained from tumour-bearing animals. In three remaining B77V-induced virogenic rat tumours (C21, C22 and C23), GS antigen was not detected with rabbit antiserum; however, sera obtained from these three tumourbearing rats contained high titres of GS antibodies when tested with different GS antigens. Positive results were obtained also with PR-RSV-induced virogenic rat tumour X C . However, all attempts to detect GS antigen in one S R -R S V induced virogenic rat tumour ( M R I ) gave negative results. Possible heterogeneity of A TV-induced GS antigen in mammalian tumours is discussed.