Studies on electrochemical behaviour of cephalexin

✍ Scribed by Qilong Li; Shouai Chen

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 546 KB
• Volume: 282
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(93)80363-p

✦ Synopsis

Cephalexin, which contains an unsubstituted 3-methyl group, but no reducible group, does not give a reduction peak at a dropping mercury electrode, whereas its degradation product does. The degradation of cephalexin was carried out in 0.1 M NaOH at 100°C for 20 min. A sensitive reduction peak of cephalexin was obtained by adsorptive stripping voltammetry in 0.1 M NaOH at an accumulation time of 60 s. The peak potential is -0.80 V (vs. Ag/AgCl). The peak current is directly proportional to the concentration of cephalexin, with a detection limit of 5.0 x lo-" M. The electrochemical behaviour of cephalexin was studied. The reduction process is quasi-reversible with adsorptive characteristics. The mechanisms of degradation and electrode reaction are discussed.