Studies on Cyclamate Sodium (Sucaryl Sodium), A New Noncaloric Sweetening Agent†

✍ Scribed by Richards, R.K. ;Taylor, J.D. ;O'Brien, J.L. ;Duescher, H.O.

• Publisher: Elsevier
• Year: 1951
• Weight: 550 KB
• Volume: 40
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030400102

✦ Synopsis

While saccharin has proved over the years to be an innocuous noncaloric sweetening agent, its instability to heating and bitter aftertaste have been distinct drawbacks. A new chemical substance, cyclohexyl sulfamate sodium (Sucaryl sodium), is less potent in sweetening power than saccharin, but withstands boiling and has a clean sweet taste. Pharmacologic studies indicate this substance to be nontoxic in acute and chronic experiments in various species. It does not exert specific physiological effect. Sucaryl sodium is excreted largely unchanged by the kidneys, has no effect upon oxygen consumption, and does not interfere with the digestive enzymes. The presence of Sucaryl sodium in the urine does not disturb the usual chemical tests or cause false positive results.