Studies on Arginine Peptides. II. Synthesis of L-Arginyl-L-arginine and other N-Terminal Arginine Dipeptides
✍ Scribed by Zervas, Leonidas; Otani, Theodore T.; Winitz, Milton; Greenstein, Jesse P.
- Book ID
- 115479455
- Publisher
- American Chemical Society
- Year
- 1959
- Tongue
- English
- Weight
- 995 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0002-7863
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## Abstract __N__^ω^‐Hydroxy‐L‐arginine (2) was prepared by a multi‐stage synthesis; the key step was the addition of hydroxylamine to the protected cyanamide 8. The presence of __N__‐hydroxyguanidines was confirmed, above all, by ^15^N‐NMR investigations. ^15^__N__^ω^‐Hydroxy‐L‐arginine (2) was co
Almtract---p-Nitroanilides of N-acylated di-, tri-and tetrapeptides with C-terminal arginine or lysine residues have been obtained, as a rule with good yields, via acylation of arginine or lysine p-nitroanilides by methyl esters of respective N-acylated peptides, catalyzed by subtilisin or ct-ehymot