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Studies on an unstable phenotype induced by UV irradiation

✍ Scribed by Claude-Michel Gaillardin; Geneviève Sylvestre; Henri Heslot


Publisher
Springer
Year
1975
Tongue
English
Weight
584 KB
Volume
104
Category
Article
ISSN
0302-8933

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✦ Synopsis


Unstable clones excreting L--lysine into their growth medium are obtained at a very high frequency following UV irradiation in both haploid and diploid strains of Saccharomycopsis lipolytica, provided they carry a mutation affecting the first enzyme of the lysine pathway and confering resistance to end product inhibition. The phenotype can be stabilized in some sublines; it appears as dominant and coupled with a decrease in spore viability. Excretion in batch cultures is confined to the end of the exponential phase, and seems not to consist in a simple release of the lysine pool content.


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