β Scribed by Elnagdi, Mohamed Hilmy ;Erian, Ayman Wahba
No coin nor oath required. For personal study only.
The alkylβsubstituted heterocyclic carbonitriles 1β3 react with elemental sulphur to yield the thienoazines 7, 11 and 13, respectively. Whereas 7 reacts with acrylonitrile to afford a [4+2] cycloaddition product with elimination of hydrogen sulphide, compounds 11 and 13 are not converted into cycloadducts. The quinoline 9a and the quinazoline 14 are obtained by reaction of 1 and 3, respectively, with formaldehyde and malononitrile. The thienopyridines 16 are produced by reaction of 6a, c with benzylidinemalonitrile. Furo[3,4βf]indazole 19 is prepared by [4 + 2] cycloaddition of the thienopyrazole 18 with maleic anhydride. The effect of the substituent of the thienyl moiety of the thienopyridazine ring system on its reactivity toward electronβpoor olefins has been investigated.
π SIMILAR VOLUMES
## Abstract ΟβAzolylacetophenones **1** and **2** react with dimethylformamide dimethylacetal to yield enaminones **7,8** that were converted into azolylazoles __via__ reaction with hydrazine and with hydroxylamine. Compounds **1,2** also coupled with aromatic diazonium salts to yield arylhydrazone