Studies on abnormal polymorphonuclear neutrophils in acute myelogenous leukemia: Clinical significance and changes after chemotherapy
✍ Scribed by Dr. T. Suda; T. Onai; T. Maekawa
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 758 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
In patients with acute myelogenous leukemia (AML), 34 out of 35 patients (97%) had cytochemically abnormal polymorphonuclear neutrophils (PMN). Some interesting regularity was noted in the appearance of cytochemical abnormalitics of the PMNs. Whcn peroxidase (PO) activity was low, both alkaline phosphatase (AP) and chloroacctate esterase (CAE) activities were also low (group A). When PO activity wah normal, if AP activity was low, CAE activity tended to be high (group B) and if AP activity was high. CAE activity tended to be low (group C). Complete remission rate of group B (65%) seemed to be better than that of group C (20%) and group A (25%) although the differences was not statistically significant. In these patients, the number of peripheral leukemic blasts and PMNs showed a significant positive correlation (r = 0.69, p < 0.005). Furthermore, patients with higher circulating PMN counts (more than 2 X lO''/L) had a significantly worse prognosis than patients with lower counts (p < 0.05). These rather unexpected findings strongly suggest that cytochemically abnormal PMNs are progeny of AML blasts. The change in the proportion of abnormal PMNs associated with chemotherapy were studied in 2 I patietns during the remission induction period. Abnormal PMNs disappeared from the circulation in patients who achieved complete remission. In contrast, abnormal PMNs persisted throughout the remission induction period in patients who failed to achieve complete remission.