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Studies of the thyrotropin-releasing hormone I. CNDO/2 studies of the conformations of the residues

✍ Scribed by Suheil F. Abdulnur; R.L. Flurry Jr.; J.M. Bopp Jr.

Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
540 KB
Volume
59
Category
Article
ISSN
0022-5193

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✦ Synopsis

The conformations of model fragments of TRH(p Glu-His-Pro-NH2) were calculated by the CNDO/2 molecular orbital method. The predicted conformations of pyroglutamic-N-methylamide and prolineamide agree well with the crystal structures of pyroglutamide and proline. Intramolecular hydrogen bonding is found to occur in both of the imidazole tautomers in histidine-N,N-dimethylamide.

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