✦ LIBER ✦

Studies of the stability and toxicity of zinc polyacrylate (polycarboxylate) cements (PAZ)

✍ Scribed by Peters, Walter J. ;Jackson, Robert W. ;Smith, Dennis C.

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 342 KB
Volume: 8
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820080107

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✦ Synopsis

Abstract

Zinc polycarboxylate cement (PAZ) was shown to actively bond to ^45^Ca in vitro, with maximum uptake occurring at a Ca^+2^ concentration of 0.2 mg/ml. When the resultant PAZ‐^45^Ca complex was subsequently incubated in the presence of high levels of unlabeled Ca^+2^, there was an exchange between the ^45^Ca bond to the cement and the Ca^+2^ in solution. When PAZ prepared using ^65^Zn was incubated with high levels of Ca^+2^, there was no exchange between the Ca and the ^65^Zn. ^14^C‐PA failed to be taken up by L‐cells in tissue culture, during 16 division cycles. Using radioactive PAZ prepared from ^14^C‐PA, the PA moiety of the cement was shown to be extremely insoluble and stable in vivo.

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