Studies of the MHC-linked “CT” alloantigenic system in rats

✍ Scribed by Thomas Sieck; Darcy B. Wilson

• Book ID: 104731025
• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 580 KB
• Volume: 14
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00342198

✦ Synopsis

Previous studies have defined a novel, MHC-linked alloantigenic system in the rat (CT) detectable with cytotoxic T cells (CTL) generated by alloimmunization and restimulation using strain combinations thought to be RT1-compatible, for instance, Lewis and Fischer 344. CTLs generated in this way are able to lyse targets from a variety of different strains without any evidence of MHC-restricted interactions, and yet these CT determinants possess properties unlike conventional class I and class II MHC gene products. The present studies employ cold target competition assays to derive a minimal estimate of the number of different CT determinants detected with Lewis anti-Fischer 344 CTLs, the number of loci involved in their expression, and their strain distribution. The results indicate that Lewis anti-Fischer CTLs define at least four different determinants encoded by at least two different loci.