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Studies of the binding mechanism between aptamers and thrombin by circular dichroism, surface plasmon resonance and isothermal titration calorimetry

✍ Scribed by Po-Hsun Lin; Ren-Hao Chen; Chung-Han Lee; Yung Chang; Chien-Sheng Chen; Wen-Yih Chen

Book ID
113550399
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
1010 KB
Volume
88
Category
Article
ISSN
0927-7765

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## Abstract In the present work the complexation mechanism between (+)‐usnic acid (UA) and cyclodextrins (CDs) has been investigated by isothermal titration calorimetry (ITC) and phase‐solubility diagrams using pH as a tool for modifying the molecule ionization. ITC experiments have been employed t