✦ LIBER ✦

Studies of metabolic control using NMR and molecular genetics

✍ Scribed by Kevin M. Brindle; Sandra M. Fulton; Helen Gillham; Simon-Peter Williams

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 147 KB
Volume: 10
Category: Article
ISSN: 0952-3499
DOI: 10.1002/(sici)1099-1352(199707/08)10:4<182::aid-jmr363>3.0.co;2-9

No coin nor oath required. For personal study only.

✦ Synopsis

The techniques of NMR spectroscopy and molecular genetics have provided new and powerful approaches to studying the control and organisation of cellular metabolism in vivo. We review here our recent applications of these methodologies to the study of energy metabolism in yeast and mammalian cells.

📜 SIMILAR VOLUMES

Genetic studies and molecular markers of

Genetic studies and molecular markers of bladder cancer

✍ Carlos Cordon-Cardo; Joel Sheinfeld; Guido Dalbagni 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 88 KB 👁 2 views

Target genes implicated in cellular transformation and tumor progression have been divided into two categories: proto-oncogenes which, when activated, become dominant events characterized by the gain of function, and tumor suppressor genes which become recessive events characterized by the loss of f

Realities and virtual realities of inbor

Realities and virtual realities of inborn errors of metabolism: Biochemical genetics in the molecular genetic era

✍ Scriver, Charles R. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB 👁 1 views

Nutritional and genetic determinants of

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: A multicenter case–control study

✍ Mirande Candito; Romain Rivet; Bernard Herbeth; Catherine Boisson; René-Charles 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 2 views

Use of fluorocitrate and fluoroacetate i

Use of fluorocitrate and fluoroacetate in the study of brain metabolism

✍ Frode Fonnum; Arnt Johnsen; Bjørnar Hassel 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 71 KB 👁 2 views

Fluoroacetate and its toxic metabolite fluorocitrate cause inhibition of aconitase. In brain tissue, both substances are preferentially taken up by glial cells and leads to inhibition of the glial TCA cycle. It is important to realise, however, that the glia-specificity of these compounds depends bo

Quantitative 13C NMR studies of metaboli

Quantitative 13C NMR studies of metabolic compartmentation in the adult mammalian brain

✍ Fátima Cruz; Sebastián Cerdán 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 494 KB 👁 1 views

We review the information obtained by 13 C NMR methods on the metabolic compartmentation of the adult mammalian brain with emphasis on its quantitative aspects. Classical radiotracer evidence and more recent 13 C NMR results support the presence in the brain of at least two glutamate pools, small an

The use and limitations of deuterated lo

The use and limitations of deuterated lorcainide in metabolism and pharmacokinetic studies

✍ C. F. Gelijkens; A. Van Peer; H. Lenoir; A. Knaeps; R. Woestenborghs; J. Heykant 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 447 KB