Studies of Imidazoles. VII. Substituted 1-Phenethylimidazoles and Related Compounds*,1
✍ Scribed by CANNON, W. N.; POWELL, C. E.; JONES, R. G.
- Book ID
- 115486780
- Publisher
- American Chemical Society
- Year
- 1957
- Tongue
- English
- Weight
- 473 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-3263
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## Abstract The Ugi four‐component condensation between cycloalkanones, isocyanides, and ammonium formate affords __N__‐substituted 1‐formylamino‐1‐cycloalkanecarboxamides 1 which are dehydrated to give the corresponding isocyanides 2. Compounds 2 are cyclized with arylsulfenyl thiocyanates to 1,3‐
## Abstract The Ugi four‐component condensation between 1,1‐diethoxy‐2‐isocyanoethane (2), cycloketones 1, amine hydrochlorides 4, and potassium thiocyanate (3a) or selenocyanate (3b) affords spiroimidazoles 5, which are cyclized to spiroimidazo[1,5‐__a__]imidazole‐5‐thiones (or selenones) 6.