Heterogeneity of the coumarin anticoagul
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Romain Lasseur; Agnès Grandemange; Christiane Longin-Sauvageon; Philippe Berny;
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Article
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2006
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John Wiley and Sons
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English
β 259 KB
Vitamin K epoxide reductase (VKOR) activity in liver microsomes from a susceptible and a genetically warfarin-resistant strain of mice (Mus Musculus domesticus) was analyzed to determine the mechanism of resistance to this 4-hydroxycoumarin derivative. Kinetic parameters for VKOR were calculated for