Studies of co-modifier and carboxylic acid for the enantio-differentiating hydrogenation of 2-octanone over a tartaric acid in situ modified nickel catalyst

✍ Scribed by Tsutomu Osawa; Yuki Nakagawa; Masashi Ando; Tadao Harada; Osamu Takayasu

• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 185 KB
• Volume: 302
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/j.molcata.2008.11.027

✦ Synopsis

The effects of a co-modifier and carboxylic acid on the hydrogenation rate and the enantio-differentiating ability (e.d.a.) were studied for the hydrogenation of 2-octanone and methyl acetoacetate over a tartaric acid modified reduced nickel catalyst. For the hydrogenation of 2-octanone, tartaric acid, pivalic acid, and Na + were necessary for the appearance of the predominant e.d.a. Sodium pivalate, instead of the typical co-modifier, NaBr, was appropriate for the in situ modification of reduced nickel. The use of sodium pivalate resulted in a higher hydrogenation rate and e.d.a.