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Studies of an outbreak of acute hepatitis A: I. Complement level fluctuation

✍ Scribed by G. M. Baer; J. A. Walker; P. A. Yager

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
374 KB
Volume
1
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

An outbreak of hepatitis A occurred in a rural elementary school in Colbert County, Alabama, in October and November 1972. The outbreak was caused by sewage‐contaminated drinking water and involved 49 children and 1 adult. Acute and convalescent serum samples were obtained from the hepatitis patients, and from each of 24 unafflicted matched controls at the same time. Strikingly, the levels of the third and fourth components of complement (C'3 and C'4) were markedly reduced in the acute samples from the sick children but returned to normal in the convalescent ones; the C'3 and C'4 levels in the healthy matched controls were not reduced. In addition, antigen‐antibody complexes were found in convalescent sera from some of the sick children. These findings indicate that immune complexes are present in acute hepatitis A and suggest that the techniques for future virus isolation may have to be altered.

πŸ“œ SIMILAR VOLUMES

Studies of an outbreak of acute hepatiti
Studies of an outbreak of acute hepatitis A: II. Antibody changes to cytomegalovirus and herpesvirus
✍ G. M. Baer; P. A. Yager; J. C. Hierholzer; J. A. Walker; J. D. Almeida πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 360 KB

## Abstract The acute and convalescent sera from 14 schoolchildren with acute hepatitis A were tested for antibody changes to 70 viral antigens. Marked decreases were noted in the levels of antibody to cytomegalovirus in 5 of the 14 children and in the levels of antibody to herpesvirus type 1 in 3.