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Studies of a DNA marker (G8) genetically linked to Huntington disease in British families

✍ Scribed by Sandra Youngman; M. Sarfarazi; O. W. J. Quarrell; P. M. Conneally; Karen Gibbons; P. S. Harper; D. J. Shaw; R. E. Tanzi; Margaret R. Wallace; J. F. Gusella

Book ID: 104700960
Publisher: Springer
Year: 1986
Tongue: English
Weight: 493 KB
Volume: 73
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00279096

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✦ Synopsis

Close genetic linkage has been shown between the DNA sequence G8 (locus D4S10) and 16 British families with Huntington disease using the HindIII, EcoR1, Nci1, and Pst1 polymorphisms detected by G8, and by combining all the polymorphisms to give a combined haplotype. Two recombinants have been detected in these families giving a maximum lod score of 17.60 at a theta of 0.02. These results confirm the originally reported linkage between the loci and provide evidence against significant multilocus heterogeneity for Huntington disease.

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Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families

✍ Ichiro Kanazawa; Ikuko Kondo; Joh-E Ikeda; Teruaki Ikeda; Yuichior Shizu; Mitsuo 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 440 KB

This is the first full report on the genetic linkage between Japanese Huntington's disease and the DNA markers D4S10 and D4S43/S127. With use of the HindIII, BglI, and EcoRI polymorphisms detected at D4S10, and the combination of all these polymorphisms to give composite haplotypes, nine Japanese Hu