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Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-Amino Acids

✍ Scribed by Hughes, Andrew B.; Sleebs, Brad E.


Book ID
115540773
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
318 KB
Volume
39
Category
Article
ISSN
0039-7911

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Effective Methods for the Synthesis of N
✍ Andrew B. Hughes; Brad E. Sleebs 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 278 KB

N-Methyl b-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1,3-oxazolidin-5-ones to synthesise N-methyl a-amino acids. Starting from a-amino acids, two approaches w