Studies in the 2,4-disubstituted adamantanes. Preparation and reactivity of pure epimeric 4-hydroxy- and 4-methoxyadamantan-2-ones
โ Scribed by Henkel, James G.; Spector, Joni H.
- Book ID
- 121304238
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 695 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
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## Abstract Facile, alternative synthetic routes to **6**, **(R)โ6**, and **(S)โ6**โ3โbenzylโ__N__โ(2,6โdimethylphenyl)โ1,3โoxazolidineโ4โcarboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**โ, **(R)โ11**โ, and *
## Abstract Six groups of diastereomeric 2,4โdisubstituted adamantanes were studied with DFTโGIAOโNBO (natural orbital analysis) methods. The calculated ^13^C chemical shifts reproduce well the experimental data. It was found that among all diastereomers, those bearing substituents in ฮดโ__syn__โaxi