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Studies in marine macrolide synthesis: stereocontrolled synthesis of a C21–C34 subunit of the aplyronines

✍ Scribed by Ian Paterson; Simon B Blakey; Cameron J Cowden


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
129 KB
Volume
43
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES


Studies in marine macrolide synthesis: S
✍ Ian Paterson; Cameron J Cowden; Michael D Woodrow 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 231 KB

The aplyronine C I-CII subunit 4, containing 4 stereocentres and the (E,E)-diene system, was prepared in 7 steps from ethyl ketone (R)-8 using a boron-mediated anti aldol reaction. The corresponding C 15-C27 subunit 5, containing 6 stereogenic centres and an (E)-alkene, was obtained in 10 steps from

Studies in marine macrolide synthesis: S
✍ Ian Paterson; Linda E Keown 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 237 KB

The C36-C46 subunit 3, containing the F ring of spongistatin 1 (1), was prepared in 12 steps from ketone (R)-7. Key steps include: (i) the boron-mediated anti aldol reaction, 7 9; (ii) the Sharpless AD, 6 --~ 13; and (iii) an intramolecular hetero-Michael addition, followed by base-promoted equilibr