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Studies directed toward the synthesis of viridenomycin. Route 1: assembly of three advanced intermediates

✍ Scribed by Albert W Kruger; A.I Meyers


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
68 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


Three enantiomerically and geometrically pure building blocks representing fragments of the antifungal antibiotic viridenomycin have been prepared.


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A second generation approach toward the synthesis of viridenomycin is described. Three key fragments of the molecule have been synthesized in stereochemically pure form. Initial studies toward the coupling of these fragments with the aim of assembling the macrocycle are detailed. Final efforts to re

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