The influence of lipids on stereoselecti
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Dion R. Brocks; Kishor M. Wasan
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Article
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2002
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John Wiley and Sons
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English
⚖ 119 KB
👁 1 views
The objective of this study was to determine the effect of lipids on the pharmacokinetics of halofantrine enantiomers. Rats were given (+/-)-halofantrine HCl 2 mg/kg i.v., or 7 mg/kg orally. Some rats were rendered hyperlipidemic by intraperitoneal administration of poloxamer 407 1 g/kg, followed by