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Structures of the troponin C regulatory domains in the apo and calcium-saturated states

✍ Scribed by Gagné, Stéphane M. ;Tsuda, Sakae ;Li, Monica X. ;Smillie, Lawrence B. ;Sykes, Brian D.

Book ID
109965116
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
740 KB
Volume
2
Category
Article
ISSN
1545-9993

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The Ca(2+)/Mg(2+)-dependent interactions between TnC and TnI play a critical role in regulating the 'on' and 'off' states of muscle contraction as well as maintaining the structural integrity of the troponin complex in the off state. In the present study, we have investigated the binding interaction