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Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases

✍ Scribed by Berman, Andrea J; Kamtekar, Satwik; Goodman, Jessica L; Lázaro, José M; de Vega, Miguel; Blanco, Luis; Salas, Margarita; Steitz, Thomas A


Book ID
110032152
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
448 KB
Volume
26
Category
Article
ISSN
0261-4189

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✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences