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Structures of peptide agonists for human protease activated receptor 2

✍ Scribed by Martin J. Stoermer; Bernadine Flanagan; Renée L. Beyer; Praveen K. Madala; David P. Fairlie

Book ID
113496476
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
440 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract Protease‐activated receptor 2 (PAR~2~) is a G protein‐coupled cell surface receptor for trypsin‐like enzymes. Proteolytic cleavage at a specific site in the extracellular __N__‐terminus exposes a receptor‐activating sequence, the ‘tethered ligand’, which binds intramolecularly to initia