Structures of ionic liquids dictate the conversion and selectivity of enzymatic glycerolysis: Theoretical characterization by COSMO-RS
✍ Scribed by Biqiang Chen; Zheng Guo; Tianwei Tan; Xuebing Xu
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 299 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0006-3592
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✦ Synopsis
Abstract
Lipase‐catalyzed glycerolysis of triolein has been examined using a group of tetraammonium‐based ionic liquids (ILs) as media, specifically with functional groups in cation part. The results demonstrated that the reaction evolution and profile specificity of respective IL system could be quantitatively associated with the structural characteristics of the IL by means of quantum chemical and COSMO‐RS calculation. Misfit interaction, Van der Waals interaction and chemical potential, etc. derived from COSMO‐RS calculation are shown to be effective measures to delineate multiple interactions of ILs and then can be used to understand the effects of ILs on reactions. The hydrophobic substituents in the cation are found to contribute to the increase of triolein solubility and enhancement of initial reaction rate; while strong polar anion and polyethoxyl and free hydroxyl groups in the cation part dictate improved product selectivity through reducing activity coefficients of monoglycerides. Integration of these structures into the same molecule constitutes a promising group of ILs that could produce over 90% monoglyceride with almost 100% triglyceride conversion, as well as bulky productivity, of particular potential for industrial applications. Overall, this work has presented a first attempt to characterize the IL structure‐dependency of reaction specificity by associating structural variations of ILs with thermodynamic property changes of resided compounds and subsequent effects on reaction specificity. This might be of general value to help to understand the multiple solvation interaction among IL reaction systems at molecular level and promote the application of IL‐mediated reactions to practical interests. Biotechnol. Bioeng. 2008;99: 18–29. © 2007 Wiley Periodicals, Inc.