Structures of Amamistatins A and B, Novel Growth Inhibitors of Human Tumor Cell Lines from Nocardia asteroides
β Scribed by Susumu Kokubo; Kiyotake Suenaga; Chikara Shinohara; Tomoko Tsuji; Daisuke Uemura
- Book ID
- 108370921
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 108 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
Two new lipopeptides, amamistatins A (1) and B, were isolated from an actinomycete. The absolute stereostructure of 1 was determined by spectroscopic and chemical analyses. Amamistatins A (1) and B showed growth inhibition for human tumor cell lines.
## Abstract Granulocytes of normal human donors were previously shown to have cytostatic activity __in vitro__ against a variety of tumor cell lines. In the present study, we have compared the levels of granulocyteβmediated cytostatic activity in cancer patients and normal donors. In an initial stu