✦ LIBER ✦

Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla—Fascaplysinopsis sponges and Didemnum tunicates

✍ Scribed by Nathaniel L Segraves; Suzette Lopez; Tyler A Johnson; Sadri A Said; Xiong Fu; Francis J Schmitz; Halina Pietraszkiewicz; Frederick A Valeriote; Phillip Crews

Book ID: 104253460
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 114 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00671-3

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✦ Synopsis

The structural variations and bioactivity properties of the alkaloids in the fascaplysin (1) and the reticulatine (3) families were examined. Four organisms were analyzed consisting of two collections of the sponge Fascaplysinopsis reticulata and two collections of the tunicate Didemnum sp. Reported are the isolation of three new compounds: 3-bromofascaplysin (2), 14-bromoreticulatine (4), and 14-bromoreticulatate (6) along with reticulatate (5) previously known as a semi-synthetic product of 1. Compounds 1 and 5 showed selectivity in a cell based cytotoxicity assay.

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