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Structure−Activity Study on the Phe Side Chain Arrangement of Endomorphins Using Conformationally Constrained Analogues

✍ Scribed by Tömböly, Csaba; Kövér, Katalin E.; Péter, Antal; Tourwé, Dirk; Biyashev, Dauren; Benyhe, Sándor; Borsodi, Anna; Al-Khrasani, Mahmoud; Rónai, András Z.; Tóth, Géza

Book ID: 126987510
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 90 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0310028

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## Abstract The discovery of endomorphins (EMs) has opened the possibility of searching for new analgesics. However, the design of peptide analgesics has proven to be very difficult as a result of their conformational flexibility and a lack of clarity in structure–activity relationships (SAR). In E