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Structure–activity relationships of some 3-substituted-4-hydroxycoumarins as HIV-1 protease inhibitors

✍ Scribed by Serge Kirkiacharian; Duong Thanh Thuy; Sames Sicsic; Robert Bakhchinian; Raffi Kurkjian; Thierry Tonnaire


Book ID
114019140
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
171 KB
Volume
57
Category
Article
ISSN
0014-827X

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A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an