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Structure–activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors

✍ Scribed by Sammy R. Shaver; Janet L. Rideout; William Pendergast; James G. Douglass; Edward G. Brown; José L. Boyer; Roshni I. Patel; Catherine C. Redick; Arthur C. Jones; Maryse Picher; Benjamin R. Yerxa


Publisher
Springer Netherlands
Year
2005
Tongue
English
Weight
262 KB
Volume
1
Category
Article
ISSN
1573-9538

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a