Aldehydes are widespread environmental and industrial compounds, able to stimulate a range of adverse health effects (e.g., general toxicity, allergenic reactions, mutagenicity, and carcinogenicity). We have previously presented quantitative structure-activity relationships (QSARs) for the genotoxic
Structure–activity relationships for the mutagenicity and carcinogenicity of simple and α-β unsaturated aldehydes
✍ Scribed by Romualdo Benigni; Laura Passerini; Andrea Rodomonte
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 108 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.10190
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## Abstract Covalent binding of reactive electrophiles to cellular targets is a molecular interaction that has the potential to initiate severe adverse biological effects. Therefore, electrophile reactivity towards biological nucleophiles could serve as an important correlate for toxic effects such
## Abstract Covalent binding of reactive electrophiles to cellular targets is a molecular interaction that has the potential to initiate severe adverse biological effects. Therefore, a measure for electrophilic reactivity with biological nucleophiles could serve as an important correlate to toxic e
In a recent article in Environmental Mutagenesis [9:289-295, 19871, "Mutagenicity and Toxicity Studies of Several a$-Unsaturated Aldehydes in the Salmonella typhimurium Mutagenicity Assay," K.O. Cooper et al provided support for a phenomenon that had been described earlier by Ames et al [1975], Maro