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Structure–Activity Relationships for Side Chain Oxysterol Agonists of Hedgehog Signaling

✍ Scribed by Corman, Audrey; DeBerardinis, Albert M.; Hadden, M. Kyle

Book ID
127283322
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
161 KB
Volume
4
Category
Article
ISSN
1948-5875

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a