Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9 R )-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

✍ Scribed by Chen, Xiao-Tao; Pitis, Philip; Liu, Guodong; Yuan, Catherine; Gotchev, Dimitar; Cowan, Conrad L.; Rominger, David H.; Koblish, Michael; DeWire, Scott M.; Crombie, Aimee L.; Violin, Jonathan D.; Yamashita, Dennis S.

• Book ID: 121321445
• Publisher: American Chemical Society
• Year: 2013
• Tongue: English
• Weight: 873 KB
• Volume: 56
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm4010829