Structure–Activity Analysis of the Growth Hormone Secretagogue GHRP-6 by α- and β-Amino γ-Lactam Positional Scanning

Examination of the active secondary stru

Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams

✍ Nicolas Boutard; Stéphane Turcotte; Kim Beauregard; Christiane Quiniou; Sylvain 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract The relationship between the conformation and biological activity of the peptide allosteric modulator of the interleukin‐1 receptor 101.10 (D‐Arg‐D‐Tyr‐D‐Thr‐D‐Val‐D‐Glu‐D‐Leu‐D‐Ala‐NH~2~) has been studied using (__R__)‐ and (__S__)‐Bgl residues. Twelve Bgl peptides were synthesized usi