Structure-specific inhibition by bile acids of adenosine triphosphate—dependent taurocholate transport in rat canalicular membrane vesicles

Bile acid inhibition of P-glycoprotein–m

Bile acid inhibition of P-glycoprotein–mediated transport in multidrug-resistant cells and rat liver canalicular membrane vesicles

✍ Roberto Mazzanti; Ornella Fantappié; Yukkio Kamimoto; Zenaida Gatmaitan; Paolo G 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 738 KB

To study the effect of bile acids on P-glycoproteinmediated drug transport, we performed experiments using multidrug resistant cells and rat canalicular membrane vesicles. Cellular accumulation and efflux of rhodamine 123 were measured in drug-resistant cells by means of computerized quantitative im